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KMID : 0377519920170010013
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Chung-Ang Journal of Medicine
1992 Volume.17 No. 1 p.13 ~ p.25
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Immunohistochemical Observation of H-ras p²¹ Expression in Gastric Neoplasms
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Abstract
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To observe the increased expression of the human H-ras p21 in tumor cells of gastric neoplasms including 10 cases of adenomatious polyp, 10 cases of early gastric carcinoma and 20 cases of advanced carcinoma, immunohistochemical studies were carried out by using avidin-biotin-complex immnoperoxidase method in formalin fixed tissue sections.
The results were as follows
1. The increased expression of H-ras p21 in gastric carcinoma depended upon the tumor differentiation.
2. Although advanced gastric carcinoma demonstrated stronger positive reaction of H-ras p21 than early carcinoma and adenomatous polyps, no correlation among advanced carcinomas and H-ras p21 expression was observed in relation to depth of tumor size, tumor invasion and lymph node metastasis (p> 0.05 ).
3. Although the adenomatous polyp of stomach showed. less positive reaction of H-ras p21 than that of gastric carcinoma, there were positive focally in 3 cases and diffusely in 2 cases. There fore, the result of this investigation suggested that increased expression of H-ras p21 was involved in the process of multistep carcinogenesis of gastric carcinoma.
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KEYWORD
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